Studys show shocking results about Pfizer vaccines

Test was carried out among several participants show how Pfizer reacts to Omicron virus

Amid the speedy spread of the Omicron variant, several measures have been taken all around the world to restrict the spread of this variant.
Researchers all around the globe are putting their full efforts to come up with vaccination to give protection against this variant too.
According to research conducted in Africa Health Research Institute, the researchers came up with a conclusion that the Pfizer Covid-19 vaccine provides less immunity against Omicron than from other corona variants.
The study showed that considerable immunity is retained in people who were both vaccinated and previously infected.
According to Professor Willem Hanekom from the Africa Health Research Institute, the clinical implications of the important laboratory data needs to be determined.
It is likely that lesser vaccine-induced protection against infection and disease would be the result.
In a statement, he added that most virologists agreed that the current vaccine will still protect against severe disease and death in the face of Omicron infection.
The main study of the researchers revolved around whether the Pfizer mRNA vaccines could destroy or fight against the antibody produced by the Omicron and if the virus still requires binding to the ACE2 receptor on human cells to infect them.
The researchers also tested the ability of plasma from Pfizer vaccinated study participants to neutralize Omicron versus ancestral D614G virus. 14 samples were drawn from 12 people, among which 6 had no Covid infection or detectable antibody.
They used a human lung cell line clone engineered to express the ACE2 receptor to both isolate the virus and test neutralization.
Representational image.
Image: Representational image.
The findings indicated that ACE2 is required for Omicron entry.
The researchers also tested the ability of plasma from Pfizer vaccinated study participants to neutralize Omicron versus ancestral D614G virus.
14 samples were drawn from 12 people, among which 6 had no Covid infection or detectable antibody.
The remaining 6 participants had a record of previous infection in the first SARS-COV-2 infection wave in South Africa where the infection was with ancestral D614G variant.
These samples had very strong neutralization of the virus, consistent with sampling soon after vaccination according to the study.
Five of the participants who were previously infected showed relatively high neutralization titers with Omicron.
The researchers noted that for Beta variant immune escape from Pfizer has been reported to be substantial with about a 3-fold reduction.
It added that the results show that Omicron shows a much more extensive escape.



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