How does the Sputnik V works?

Before taking any vaccine or medication, it is notably essential for us to understand its preparation and its working in our body, as well as its side effects.

Dr Reddy's laboratory in Hyderabad, India, has sought the approval from Drug Controller General to use Sputnik V in India for emergency use.
The Russian Direct Investment Fund partnered with Dr Reddy's in September 2020 to conduct the clinical trials.
It is the 3rd vaccine to be manufactured in India next to Covaxin and Covishied.
So before we take this as a vaccine, it is necessary to know how it works.
Sputnik V uses two viruses called Adeno Virus that causes the common cold in humans. The Adeno Virus is weakened in order to stop or restrict its growth in the human body. The Adenovirus are DNA that ranges from 70-90 nanometres which may induce much illness in humans like cold, respiratory infections etc.
They are preferred for vaccines as their DNA is double-stranded, which makes them genetically more suitable. The rabies vaccine is an example of an adenovirus vaccine.
Since these adenoviruses vectors are based on natural viruses that some humans might already have been exposed to, this vaccination might not work for everyone.
Since these adenoviruses vectors are based on natural viruses that some humans might already have been exposed to, this vaccination might not work for everyone.
Sputnik V vaccine
Image: Sputnik V vaccine
In every show, two different adenoviruses are injected into the body as a vector or carrier of the weakened virus.
Before injecting into the body, these viruses are given a slight modification to ensure that when the actual virus tries to attack our body, it can mount an immune response in the form of an antibody.
A coronavirus spike protein is added to it. The coronavirus spike protein is the main protein that penetrates human cells and prevents infection. We can even say that it forms an antibody that protects our body.
This vaccine is based on the DNA of a SARS-CoV-2 type Adenovirus which is a common cold virus. That uses the weakened virus to deliver small parts of the pathogen and stimulate an immune response.
A gap of 21 days is kept between two of its doses.
It can be stored at 2 to 8 degree Celsius in a conventional refrigerator in its freeze-dried form.



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