ZyCov D, India's first needle-free and second indigenous Covid-19 vaccine has been launched in Bihar's Patna. Dr Vibha Singh, a Civil Surgeon who was involved in the vaccination process said that they have started administering this vaccine at three cities in the state namely- the Patliputra Sports Complex, Polytechnic College and Gurunanak Bhawan where there are provisions of 24*7 vaccinations.
She added that the technique is this vaccine is painless and is induced through a special injector named Pharmajet on day 0, day 28 and the last dose on day 56th. Dr Singh added that there are very less adverse effects of this vaccine. As this is a DNA vaccine, it forms antibodies very quickly.
It is India's fifth approved vaccine and the world's first Plasmid DNA vaccine, which is administered intra-dermally. This vaccine come under the category of nucleic acid vaccines in which a portion of the genetic code DNA or RNA in the SarsCOV 2 virus, is used to stimulate an immune response against its spike protein. A genetically designed plasmid is injected into a host cell, which then produces antibodies against the antigen.
Unfortunately, SARS-CoV-2 is constantly mutating and the virus spike protein itself is changing. This raises the prospect of "vaccine escape", where changes to the spike protein mean the immune system is no longer able to recognize itImmunization arms our immune system to look out for and block viruses, or destroy cells that carry the spike protein, protecting us from COVID-19 disease. Unfortunately, SARS-CoV-2 is constantly mutating and the virus spike protein itself is changing. This raises the prospect of "vaccine escape", where changes to the spike protein mean the immune system is no longer able to recognize it.
It offers a possible future alternative to people who fear needle-based jabs and, if successful, it could be scaled up and manufactured as a powder to boost global vaccination efforts, particularly in low and middle-income countries.
Pharmaceutical company Zydus has supplied its DNA Plasmid-based coronavirus vaccine " ZyCoV-D -- to the Centre from the newly commissioned Zydus Vaccine Technology Excellence Centre (VTEC) at the Zydus Biotech Park in Ahmedabad's Changodar. In November last year, the company received an order to supply 1 crore doses of the COVID-19 vaccine to the Indian government.
This vaccine will be priced at Rs 265 per dose and the applicator will be offered at Rs 93 per dose excluding GST.